PW03-014B - Gene-expression profiling study in FMF families
نویسندگان
چکیده
Introduction The inflammasome complex and the inflammatory pathway have been implicated in the pathogenesis of familial Mediterranean fever (FMF), and recently ASC (apoptosis-associated speck-like protein containing a CARD) mRNA expression was found to be up-regulated in patients carrying MEFV mutations independent of the mutation type. Gene-expression profiling has the capacity to reveal transcriptome profiles to discriminate disease “phenotypes” to understand a given disease and bring to light new diagnostic and predictive biomarkers.
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